If you want to remove a stop from the trip's itinerary during navigation:

1. Tap the bar on the center display at the bottom of the CoPilot screen.
2. The navigation screen draw opens. Tap Clear Stop.
3. The Clear Stop pop-up opens. Tap Clear Stop again to remove the trip's next stop. 
4. CoPilot recalculates your trip to navigate you to the next stop in the trip's itinerary.